2021-03-02 · sialic acid-binding Ig-like lectin 10, sialic acid binding Ig-like lectin 10 Ig-like lectin 7, siglec-like gene 2, siglec-like protein 2. GeneRIFs: Gene References Into Functions. Siglec-10 expression is up-regulated in activated human CD4(+) T cells. The synthesis and degradation of sialic acid are distributed in different compartments of the cell. The synthesis starts in the cytosol, where N-acetylmannosamine 6 phosphate 2009-10-22 · ABO blood group glycans modulate sialic acid recognition on erythrocytes. Cohen M(1), Hurtado-Ziola N, Varki A. Author information: (1)Glycobiology Research and Training Center, Departments of Medicine and Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA. X-ray crystallographic analysis of 52SFK in complexwith sialic acid revealed a new sialic acid binding site compared to otherknown adenovirus:glycan interactions. Moreover, glycan array analysisidentified α2,8-linked oligosialic acid, mimicking the naturally occurringpolysialic acid (PSia), as a potential sialic acid-containing glycan receptor for52SFK.
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This kit uses a new and improved high-throughput workflow for the preparation, separation, and detection of sialic acids labeled with 1,2-diamino-4,5-methylenedioxybenzene (DMB). Sialic acid capping at the non-reducing terminal of N- or O-glycans can serve Summary: This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. Expression studies in COS7 cells confirmed that this gene encodes a functional sialidase. Its cytosolic localization was demonstrated by cell fractionation experiments. [provided by RefSeq, Jul 2008] Summary: This gene encodes an enzyme which removes 9-O-acetylation modifications from sialic acids.
131-48-6. NSC111756. 5-acetamido-2,4-dihydroxy-6- (1,2,3-trihydroxypropyl)oxane-2-carboxylic acid.
They are found primarily on the surface of immune cells and are a subset of the I-type lectins. There are 14 different mammalian Siglecs, providing an array of different functions based on cell surface receptor-ligand interactions.
More Molecular Weight. 309.27 g/mol. Date s. Sialic acid was first isolated from bovine saliva by Gunnar Blix and concurrently from human brain lipids by Ernst Klenk, who coined the term neuraminic acid for his brain-derived monosaccharide. 1–3 Klenk went on to purify sialic acid-containing glycosphingolipids from human brain and recommended the name “ganglioside” for them as a group. 4 Consistent with his structural determination, gangliosides …
Sialic definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it up now!
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From Ancient Greek σίαλον (síalon, “spittle, saliva”) + -ic. AdjectiveEdit. sialic (not comparable). Of or pertaining to saliva. Apr 14, 2021 Influenza viruses use sialic acid residues on the surface of vertebrate cell membranes as receptors for infecting cells.
Sialic acids represent a family of sugar molecules with an unusual and highly variable chemical structure that are found mostly in the terminal position of oligosaccharide chains on the surface of
Sialic acids are found widely distributed in animal tissues and to a lesser extent in other species ranging from plants and fungi to yeasts and bacteria, mostly in glycoproteins and gangliosides. It has been shown recently that sialic acid level may be associated with developmental and pathological stages.
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Salla disease. Salla disease is an extremely rare illness which is considered the mildest form of the free sialic acid accumulation disorders though its childhood form is considered an aggressive variant and people who suffer from it have mental retardation. Sialic definition is - of, relating to, or being relatively light rock that is rich in silica and alumina and is typical of the outer layers of the earth. Sialic acids (Sias) comprise a family of 9-carbon carboxylated sugars. The Sia family consists of nearly 50 members that are derivatives of N-acetylneuraminic acid (Neu5Ac), N-glycolylneuraminic acid (Neu5Gc), and 3-deoxy-d-glycero-d-galacto-non-2-ulopyranosonic acid (deaminoneuraminic acid; 2-keto-3-deoxy-d-glycero-d-galacto-nononic acid; Kdn) (Fig.
1. Of, relating to, or producing saliva. 2. sialic acid.
Definition of sialic acid. : any of a group of reducing amido acids that are essentially carbohydrates and are found especially as components of blood glycoproteins and mucoproteins. Sialic acid is primarily present on biopharmaceuticals linked as alpha2,3 or alpha2,6. SialEXO is a broad acting sialidase mix that will hydrolyze all sialic acid linkages including alpha2,3, alpha2,6, and alpha2,8. Sialic acids represent a family of sugar molecules with an unusual and highly variable chemical structure that are found mostly in the terminal position of oligosaccharide chains on the surface of Sialic acids are found widely distributed in animal tissues and to a lesser extent in other species ranging from plants and fungi to yeasts and bacteria, mostly in glycoproteins and gangliosides. It has been shown recently that sialic acid level may be associated with developmental and pathological stages.