Furosemide - Engelska - Bulgariska Översättning och exempel


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Furosemide (frusemide) is a potent loop diuretic used in the treatment of oedematous states associated with cardiac, renal and hepatic failure, and for the treatment of hypertension. Therapy is frequently complicated by apparently erratic systemic availability from the oral route and from unpredictable responses to a given dosage. The exact mechanism of action is not fully understood, but The furosemide pharmacokinetics in healthy volunteers and in patients with renal insufficiency and hepatic cirrhosis is presented. On the average, 70 % of the oral furosemide dose is absorbed.

Furosemide pharmacokinetics

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Refrigeration may result in precipitation or crystallization; however, resolubilization at room temperature or warming may be performed without affecting the drug's stability. Infusion solution in D5W, NS, or LR is stable for 24 hours at room temperature. Professional guide for Furosemide. Includes: pharmacology, pharmacokinetics, contraindications, interactions and adverse reactions. Pharmacokinetics of furosemide following the GRDF administration, as compared to the tablet, showed lower C max and indicated a prolonged absorption phase leading to longer mean residence time in the stomach.

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Furosemide pharmacokinetics

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Furosemide is a diuretic that is used in anti-hypertensive therapy and for the relief of edema. After oral administration furosemide is rapidly but incompletely absorbed, resulting in an oral bioavailability of ~60 %. Peak plasma drug concentrations are reached 1-2h after oral administration. Because furosemide is bound extensively to Pharmacokinetics and pharmacodynamics of furosemide after direct administration into the stomach or duodenum. The pharmacokinetics and pharmacodynamics of furosemide were compared after an oral administration or a direct administration of Lasix into the duodenum in humans (40 mg). Furosemide was absorbed quickly after a direct administration of Furosemide (frusemide).

Furosemide pharmacokinetics

The apparent volume of drug distribution was not affected by the dose and averaged 11.4 % of body weight.
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Furosemide strongly binds to plasma proteins (91-99%) (34), particularly to anionic sites on albumin (20).

Page 1 of 27 Pharmacokinetics of furosemide in advanced renal failure.
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There were no significant differences (p > 0.05) between the 2 ethnic groups in either the area under the plasma concentration time curve (AUC) or the time to maximal plasma concentration (tmax).

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Twelve hypertensive parturient women under methyldopa (250 mg/8 h) and/or pindolol (10 mg/12 h) treatment received a 40‐mg single oral dose of furosemide 1 to 10 hours before delivery by cesarean section. The pharmacokinetics and bioavailability of furosemide were determined following intravenous (IV), intramuscular (IM), and subcutaneous (SC) administrations at 2.5 mg/kg dose in sheep. The literature on furosemide pharmacokinetics and pharmacodynamics is critically reviewed, concentrating on those papers published subsequent to the 1979 reviews of this topic. Intravenous and oral data are presented for healthy volunteers and for patients with various disease states. Pharmacokinetics of furosemide after intravenous, oral and transdermal administration to cats. Furosemide was rapidly eliminated in cats after oral and IV administration and is probably best administered orally at least q12h in cats with heart failure.

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